JDM Research has proven capabilities and state-of-the-art infrastructure to provide high quality (OECD GLP), reliable toxicology testing services in the field of product safety assessment to clients throughout the world following OECD, EPA, EU and other test guidelines by a dedicated team of qualified and experienced study directors, senior scientists and toxicologists supported by dedicated veterinarian and animal technicians with special toxicology training, necropsy specialists and pathologists.

 

Trusted partner of choice

A contract research organization (CRO), JDM Research performs a wide range of Preclinical Toxicology studies, including, Mammalian Toxicity, Genetic Toxicology (Mutagenicity), Ecotoxicology, Biocompatibility studies, for pharmaceutical, crop protection / agrochemical, biotechnological, chemical and medical devices industries which wish to obtain national and international registration for their new products, with the respective Governmental regulatory authorities.

 

Experimental Animal house

State of art double corridor system, comprising 50 animal rooms constructed with a clean room modular wall and ceiling panels and completely Specific pathogen free (SPF) facility with HVAC (350 TR) system to maintain controlled environment as per the national and international guidelines. like CPCSEA and AAALAC/FELASA, for housing and maintaining test systems: Rat, mouse, guinea pig, rabbit, Fish, Birds, Daphnia, Earthworm etc.

 

Testing Facilities

Spread over 65,000 square feet. ISO Class 100,000 clean room facility
 

Biochemistry Analyser
Hematology Analyser
Histopath Equipment
Inhalation Exposure System
Coagulation Analyzer
Urine Analyser
Multimode Microplate Reader
Tissue Embeder
Microtome
Tissue Processor
Heratherm Incubator
Cooling Centrifuge
BOD Incubator
Ultra Low Temperature Freezer
Steam Steriliser (Walk In Autoclave)
Biosafety Cabinet

Biosafety, ethics and animal welfare

The norms of use and care of laboratory animals at JDM Research comply with the national and international standards including those prescribed by Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA). The Institutional Biosafety Committee (IBSC),the Institutional Ethics Committee (IEC), the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC International), ensure that the laboratory SOPs and the study plans are compliant with ethical and safe practices. 

 

Bio-compatibility testing of medical devices

JDM Research offers full range of bio-compatibility testing as required by the medical device industry in accordance with ISO 10993-1 and FDA guidelines.

Acute toxicity studies OECD Guidelines
Acute Oral Toxicity (Rat/Mice) 420, 423, 425
Acute Dermal (Rat) 402
Acute Inhalation (Rat) 403
Dermal irritation/ Corrosion (Rabbit) 404
Eye irritation/ Corrosion Rabbit 405
Skin Sensitization (Maximization Test and Buehler Test) in Guinea Pig 406
Repeated dose toxicity studies OECD Guidelines
28/ 90 / 180 Days Oral 407, 408, 409
28/90 Days Inhalation 412, 413
28/ 90 / 180 Days Dermal 410, 411
Chronic / Combine Carci Toxicity Study 452 / 453
Carcinogenicity Study 451
Reproduction toxicity studies OECD Guidelines
One Generation Toxicity Study 415
Reproduction/Developmental Toxicity Screening Test 421
Combined Repeated Dose Toxicity Study with Reproduction/ Developmental Toxicity Screening Test 422
Two Generation Toxicity Study 416
Prenatal Developmental Toxicity Study 414
Genotoxicity studies (in vitro) OECD Guidelines
Bacterial Reverse Mutation Test (Ames Test) 471
Micronucleus Test 473
Mammalian Chromosome Aberration Test 483
• Using Chinese Hamster Ovary – K1 Cell line  
• Using Human Peripheral blood Lymphocytes  
Mammalian cell Gene Mutation Test (HPRT assay) 476
Micronucleus test  
• Using Human Lymphocytes from Healthy Donor 487
• Using Chinese Hamster Ovary (CHO) – K1 cell line  
Genotoxicity studies (in vivo) OECD Guidelines
Mammalian Erythrocyte Micronucleus Test 474
In Mice/ Rat (With and without Toxicokinetic)  
Mammalian Bone Marrow chromosome Aberration Test In Mice/ Rat (With and without Toxicokinetic) 475
Mammalian alkaline comet assay 489
Eco-toxicology studies OECD Guidelines
Acute Oral and Dietary Studies of Chicken/ Pigeon 205, 206
Acute and Repeated dose toxicity to Fresh water fish 203
Acute immobilization and reproduction studies on Daphnia magna 202, 211
Effects on algal growth inhibition 201
Oral and contact toxicity to honey bees 213, 214
Acute and Reproduction Toxicity to earthworms 207, 222
(In vitro) alternate to animal studies OECD Guidelines
Skin Absorption : In Vitro Method 428
In Vitro Skin corrosion Test - RhE method 431
Bovine Corneal Opacity & Permeability Assay (BCOP) In vitro test for evaluation of eye irritation based 437
on opacity and permeability 492
In Vitro Eye Irritation 439
In Vitro Skin irritation Test 442C, 442D
In Vitro Skin Sensitization  
Bio-compatibility testing of medical devices Guidelines
Cytotoxicity ISO 10993-5
Sensitization ISO 10993-10
Systemic Toxicity ISO 10993-11
Genotoxicity ISO 10993-3
Implantation ISO 10993-6
Hemocompatibility ISO 10993-4