Striving for Innovation, this service of JDM Research is backed by a team of Professionals with expertise in Chemistry.

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R & D Synthesis

  • Development of New Actives / Enantiomers
  • Crystal Structure / Polymorph Study
  • Process Optimization / Trouble Shooting
  • Process Validation
  • Purification (Fractional Distillation / Crystallization)
  • Standard Preparation (Active and its Impurities)

Capabilities

  • Hazardous Reaction - Cyanation, Grignard, etc.
  • Chlorination - using Cl2 gas, SOCl2, SO2Cl2, etc.
  • Bromination
  • Air Sensitive Reaction - using n-BuLi, LiAlH4, NaH, etc.
  • High Pressure Reaction
  • Hydrogenations (Raney Ni / Pd-C)
  • Diazotization, Oxidation, Reduction, Nitration, Sulfonation, Acetylation, Friedel-craft, Sandmeyer, Wittig, Hoffmann Reaction, Suzuki Coupling, etc.
  • Chiral Synthesis

Infrastructure

  • Fume Hoods (Bench top / Walk-in)
  • Autoclaves
  • Rotavapors
  • Low / High Temperature Reactions Facility
  • Vacuum Pumps
  • Flash Chromatography

R & D is supported by Analytical Research Laboratory

  • Analysis (Raw Materials / Intermediates / Finish Products)
  • Method Development & Method Validation
  • Impurity Isolation
  • HPLC (RI / UV / PDA), GC (FID / TCD), Preparative HPLC, UV-Visible Spectrophotometer, Melting Point, Moisture Analyser, KF Analyser, Potentiometer, etc.

What we can do for you

  • You have a medicinal chemistry route and need to make 100-250 g for GLP Tox studies
  • Develop robust route for Tox / Phase-1 Studies (Process Research)
  • Replace route improving uses of toxic or hard to handle reagents. Develop green environmental friendly chemistry
  • Substitute multiple chromatographic separations (significant loss in yields) with suitable crystallization / purification method
  • Develop a cost effective route for up scale to be competitive
  • Reduce the number of steps, or decrease the cycle time to release capacit
  • Impurity Profiling
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Equipment

Buchi Rotavapor
CombiFlash
Hydrogenarator
Lyophilizer
Vaccum Dryer
Vacuum Pump